Bangladesh Bank (BB) Governor Abdur Rouf Talukder resigned from his post on Friday, citing personal and health reasons.
According to an BB official Talukder sent his resignation letter virtually to the official concerned at the Finance Ministry.
The development comes four days after Sheikh Hasina fled Bangladesh after resigning from the position of the prime minister on August 5 in the face of an uprising.
A day later, more than a hundred officials of the central bank stormed the governor's office demanding his resignation.
According to sources within Bangladesh Bank, Talukder has not been present at the office since former prime minister Sheikh Hasina's departure on Monday, triggered by a mass uprising led by the Anti-Discriminatory Student Movement.
On August 7, four deputy governors of Bangladesh Bank also agreed to resign due to mounting criticism.
Of these, only Deputy Governor Kazi Sayedur Rahman officially submitted his resignation to the executive director-1 of the central bank.
The other deputy governors have indicated that they will resign soon.
The deputy governors were escorted out by protesting bank staff, who accused them of enabling the misappropriation of the country's financial assets.